Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis

被引：41

作者：

Bifulco, M ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, Salerno, Italy

来源：

LIFE SCIENCES | 2005年 / 77卷 / 14期

关键词：

isoprenoid pathway; farnesol and geranylgeraniol; prenylated proteins; ras; 2; 3 '-cyclic nucleotide 3 '-phosphodiesterase (CNP); rab; FRTL-5 thyroid cells;

D O I：

10.1016/j.lfs.2005.05.017

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The isoprenoid pathway, by its end-products lipids, has an important role in the control of ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis. In particular, prenylation, a post-translational addition of famesol and geranylgeraniol, is an important event for the biological activity of many proteins that play critical roles in signal transduction and cytoskeletal regulation, as well as in cell proliferation and apoptosis. We have been interested in studying the: (a) regulation of the isoprenoid pathway in the processing of cellular transformation induced by the K-ras oncogene, (b) role of the isoprenoid pathway in the control of cell proliferation and apoptosis, (c) role of the isoprenoid pathway in the control of cytoskeleton organization and (d) control of Rab expression by the isoprenoid pathway. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1740 / 1749

页数：10

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