Selectively Expanding Subsets of T Cells in Mice by Injection of Interleukin-2/Antibody Complexes: Implications for Transplantation Tolerance

被引：24

作者：

Boyman, O. ^{[1
,2
]}

Krieg, C. ^{[1
]}

Letourneau, S. ^{[3
]}

Webster, K. ^{[4
]}

Surh, C. D. ^{[5
,6
]}

Sprent, J. ^{[4
,6
]}

机构：

[1] Univ Zurich, Lab Appl Immunobiol, Zurich, Switzerland

[2] Univ Zurich Hosp, Allergy Unit, CH-8091 Zurich, Switzerland

[3] Univ Lausanne Hosp, Lausanne, Switzerland

[4] Garvan Inst Med Res, Sydney, NSW, Australia

[5] Scripps Res Inst, San Diego, CA USA

[6] POSTECH WCU, Div IBB, Pohang, South Korea

来源：

TRANSPLANTATION PROCEEDINGS | 2012年 / 44卷 / 04期

关键词：

EXPANSION; CYTOKINES; IL-2;

D O I：

10.1016/j.transproceed.2012.01.093

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The biological activity of interleukin (IL)-2 and other cytokines in vivo can be augmented by binding to certain anti-cytokine monoclonal antibodies (mAb). Here, we review evidence on how IL-2/anti-IL-2 mAb complexes can be used to cause selective stimulation and expansion of certain T-cell subsets. With some anti-IL-2 mAbs, injection of IL-2/mAb complexes leads to expansion of CD8 T effector cells but not CD4 T regulatory cells (Tregs); these complexes exert less adverse side effects than soluble IL-2 and display powerful antitumor activity. Other IL-2/mAb complexes have minimal effects on CD8 T cells but cause marked expansion of Tregs. Preconditioning mice with these complexes leads to permanent acceptance of MHC-disparate pancreatic islets in the absence of immunosuppression.

引用

页码：1032 / 1034

页数：3

共 9 条

[1] Selective stimulation of T cell subsets with antibody-cytokine immune complexes [J].