Polymeric micelles as carriers of diagnostic agents

被引：122

作者：

Trubetskoy, VS ^{[1
]}

机构：

[1] Mirus Corp, Madison, WI 53711 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1999年 / 37卷 / 1-3期

关键词：

contrast agents; imaging; particulates; micelles; amphiphilic block copolymers; drug carriers;

D O I：

10.1016/S0169-409X(98)00100-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review deals with diagnostic applications of polymeric micelles composed of amphiphilic block-copolymers. In aqueous solutions these polymers spontaneously form particles with diameter 20-100 nm. A variety of diagnostic moieties can be incorporated covalently or non-covalently into the particulates with high loads. Resulting particles can be used as particulate agents for diagnostic imaging using three major imaging modalities: gamma-scintigraphy, magnetic resonance imaging and computed tomography. The use of polyethyleneoxide-diacyllipid micelles loaded with chelated In-111/Gd3+ as well as iodine-containing amphiphilic copolymer in percutaneous lymphography and blood pool/liver imaging are discussed as specific examples. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

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页码：81 / 88

页数：8

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