In vitro antiviral activity of adenosine analog NITD008 against tick borne flaviviruses

被引：43

作者：

Lo, Michael K. ^{[1
]}

Shi, Pei-Yong ^{[2
,3
]}

Chen, Yen-Liang ^{[3
]}

Flint, Mike ^{[1
]}

Spiropoulou, Christina F. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA USA

[2] Univ Texas Med Branch, Sealy Ctr Struct Biol & Mol Biophys, Dept Phamarcol & Toxicol, Dept Biochem & Mol Biol, Galveston, TX 77555 USA

[3] Novartis Inst Trop Dis, Singapore, Singapore

来源：

ANTIVIRAL RESEARCH | 2016年 / 130卷

关键词：

Flavivirus; NITD008; Antiviral; Nucleoside analog; Tick-borne; KYASANUR-FOREST-DISEASE; NUCLEOSIDE INHIBITOR; HEMORRHAGIC-FEVER; VIRUS; ENCEPHALITIS; EUROPE;

D O I：

10.1016/j.antiviral.2016.03.013

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study, we describe the in vitro antiviral activity of adenosine analog NITD008 against KFDV, AHFV, OHFV, as well as Tick borne Encephalitis virus (TBEV). Alongside the well-established activity of NITD008 against mosquito borne flaviviruses, our results have demonstrated the feasibility of identifying nucleoside analog inhibitors that have pan-flavivirus activity. Published by Elsevier B.V.

引用

页码：46 / 49

页数：4

共 17 条

[1]

Epidemiology of tick-borne encephalitis (TBE) in Europe and its prevention by available vaccines [J].

Amicizia, Daniela ;

Domnich, Alexander ;

Panatto, Donatella ;

Lai, Piero Luigi ;

Cristina, Maria Luisa ;

Avio, Ulderico ;

Gasparini, Roberto .

HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2013, 9 (05) :1163-1171

[2]

HIV-1 Antiretroviral Drug Therapy [J].

Arts, Eric J. ;

Hazuda, Daria J. .

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2012, 2 (04)

[3]

Sofosbuvir for the treatment of hepatitis C virus [J].

Asselah, Tarik .

EXPERT OPINION ON PHARMACOTHERAPY, 2014, 15 (01) :121-130

[4]

Tick-borne encephalitis: A review of epidemiology, clinical characteristics, and management [J].

Bogovic, Petra ;

Strle, Franc .

WORLD JOURNAL OF CLINICAL CASES, 2015, 3 (05) :430-441

[5]

DANDAWATE CN, 1994, INDIAN J MED RES, V99, P152

[6]

Zoonotic tick-borne flaviviruses [J].

Dobler, Gerhard .

VETERINARY MICROBIOLOGY, 2010, 140 (3-4) :221-228

[7]

Ancient Ancestry of KFDV and AHFV Revealed by Complete Genome Analyses of Viruses Isolated from Ticks and Mammalian Hosts [J].

Dodd, Kimberly A. ;

Bird, Brian H. ;

Khristova, Marina L. ;

Albarino, Cesar G. ;

Carroll, Serena A. ;

Comer, James A. ;

Erickson, Bobbie R. ;

Rollin, Pierre E. ;

Nichol, Stuart T. .

PLOS NEGLECTED TROPICAL DISEASES, 2011, 5 (10)

[8]

Inhibitors of the Tick-Borne, Hemorrhagic Fever-Associated Flaviviruses [J].

Flint, Mike ;

McMullan, Laura K. ;

Dodd, Kimberly A. ;

Bird, Brian H. ;

Khristova, Marina L. ;

Nichol, Stuart T. ;

Spiropoulou, Christina F. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (06) :3206-3216

[9]

Vaccination and Tick-borne Encephalitis, Central Europe [J].

Heinz, Franz X. ;

Stiasny, Karin ;

Holzmann, Heidemarie ;

Grgic-Vitek, Marta ;

Kriz, Bohumir ;

Essl, Astrid ;

Kundi, Michael .

EMERGING INFECTIOUS DISEASES, 2013, 19 (01) :69-76

[10]

Kyasanur forest disease [J].

Holbrook, Michael R. .

ANTIVIRAL RESEARCH, 2012, 96 (03) :353-362

← 1 2 →