Soluble tumor necrosis factor receptor (p75) fusion protein (Enbrel) as a therapy for rheumatoid arthritis

被引：69

作者：

Moreland, LW

机构：

[1] Univ Alabama, Dept Med, Birmingham, AL 35294 USA

[2] Univ Alabama, Arthrit Clin Intervent Program, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 1998年 / 24卷 / 03期

关键词：

D O I：

10.1016/S0889-857X(05)70027-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Soluble tumor necrosis factor (TNF) receptor fusion protein (p75) (Enbrel) is a reversible inhibitor of the biologic effects of TNF Enbrel has been shown in placebo-controlled trials to significantly improve the signs and symptoms of rheumatoid arthritis. Clinical trials are now in progress to assess the safety and efficacy of Enbrel in combination with methotrexate in refractory rheumatoid arthritis along with trials to compare Enbrel to methotrexate in patients with early rheumatoid arthritis.

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页码：579 / +

页数：14

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