Congenital leukaemia after heavy abuse of permethrin during pregnancy

被引：26

作者：

Borkhardt, A ^{[1
]}

Wilda, M ^{[1
]}

Fuchs, U ^{[1
]}

Gortner, L ^{[1
]}

Reiss, I ^{[1
]}

机构：

[1] Childrens Univ Hosp Giessen, D-35392 Giessen, Germany

来源：

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION | 2003年 / 88卷 / 05期

关键词：

D O I：

10.1136/fn.88.5.F436

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A single case is described of congenital leukaemia with 11q23/MLL rearrangement in a preterm female newborn. Because of arachnophobia, the mother had heavily abused aerosolised permethrin, a widely used household insecticide. Permethrin is considered comparatively safe, but, in view of the mother's history, its potential to induce cleavage of the MLL gene in cell culture was tested. Incubation of the BV173 cell line with 50 muM permethrin readily induced MLL cleavage.

引用

页码：F436 / F437

页数：2

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