Melatonin: structural characterization of its non-enzymatic mono-oxygenate metabolite

被引：20

作者：

Agozzino, P

Avellone, G

Bongiorno, D

Ceraulo, L

Filizzola, F

Natoli, MC

Livrea, MA

Tesoriere, L

机构：

[1] Dipartimento Chim & Tecnol Farmaceut, Palermo, Italy

[2] Dipartimento Chim Organ E Paterno, Palermo, Italy

[3] Dipartimento Farmacochim Tossicol & Biol, Palermo, Italy

来源：

JOURNAL OF PINEAL RESEARCH | 2003年 / 35卷 / 04期

关键词：

1D and 2D nuclear magnetic resonance; mass spectra; melatonin; metabolites; structure;

D O I：

10.1034/j.1600-079X.2003.00086.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Oxidation of melatonin by Fenton reagents as well as with hypochlorous acid or oxoferryl hemoglobin has been investigated. Analysis of products by low resolution/mass spectra ( MS), high resolution/MS, H-1-nuclear magnetic resonance (NMR), C-13-NMR, correlated spectroscopy ( COSY) and heterocorrelated spectroscopy (HETCOR) 2D NMR reveals the formation of a single mono-oxygenated product under all conditions and unequivocally assigns the N-[2-(5-methoxy-2-oxo-2,3-dihydro-1H-indol-3- yl)-ethyl]-acetamide structure, which had not been previously considered.

引用

收藏

页码：269 / 275

页数：7

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