Getting muscles moving again after botulinum toxin: novel therapeutic challenges

被引：45

作者：

Foran, PG

Davletov, B

Meunier, FA ^{[1
]}

机构：

[1] Univ Queensland, Dept Physiol & Pharmacol, St Lucia, Qld 4070, Australia

[2] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, Ctr Neurobiochem, London SW7 2AZ, England

[3] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2003年 / 9卷 / 07期

关键词：

D O I：

10.1016/S1471-4914(03)00113-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of botulinum neurotoxins for the treatment of muscle hyperactivity and spasticity disorders has been remarkably successful, owing to the abilities of the toxins to elicit prolonged localized paralysis and the rarity of serious adverse effects. However, botulinum toxins are the most deadly protein toxins known, and existing antidotes possess limited effectiveness. Paradoxically, in situ, the intoxicated motoneuron does not die. It reacts by emanating a sprouting network known to implement new functional synapses, leading to resumption of neurotransmission. Recent studies have highlighted ways of accelerating this natural recovery process to overcome paralysis successfully. Developing new therapeutic strategies and treatments for botulism will require more research into the molecular understanding of this 'naturally occurring' recovery process.

引用

页码：291 / 299

页数：9

共 44 条

[1] Efficacy of a novel metalloprotease inhibitor on botulinum neurotoxin B activity [J].