Synthesis, structure, and spectroscopic properties of acetato(dimethyl)(pyridine-2-carbaldehydethiosemicarbazonato)tin(IV) acetic acid solvate, [SnMe(2)(PyTSC)(OAc)]center dot HOAc. Comparison of its biological activity with that of some structurally related diorganotin(IV)bis(thiosemicarbazonates)

The synthesis, X-ray structure, behavior in solution, and biological properties of the complex [SnMe(2)(PyTSC)(OAc)].HOAc (HPyTSC = pyridine-2-carbaldehydethiosemicarbazone) are reported. The tin atom of this complex is coordinated to an N,N,S-tridentate PyTSC(-) anion, to a monodentate acetate ion, and to the two methyl groups in an approximately pentagonal bipyramidal environment with a vacant equatorial position. The complex partially evolves in DMSO and in DMSO/CHxCl4-x (X = 1, 2) mixtures, giving HPyTSC and SnMe(2)(OAc)(2). [SnMe(2) (PyTSC)(OAc)].HOAc, [SnMe(2)(DAPTSC)], and [SnPh(2)(DAPTSC)].2DMF (H(2)DAPTSC = 2,6-diacetylpyridine bis(thiosemicarbazone)) all suppress proliferation of Friend erythroleukaemia cells (FLC). DMSO-induced differentiation of FLC is slightly suppressed by [SnMe(2)(DAPTSC)] and is unaffected by [SnPh(2)(DAPTSC)].2DMF and [SnMe(2)(PyTSC)(OAc)].HOAc.