Duration of neurofibrillary changes in the hippocampal pyramidal neurons

被引：38

作者：

Bobinski, M

Wegiel, J

Tarnawski, M

Bobinski, M

de Leon, MJ

Reisberg, B

Miller, DC

Wisniewski, HM

机构：

[1] New York State Inst Basic Res Dev Disabil, Dept Pathol Neurobiol, Staten Isl, NY 10314 USA

[2] NYU, Med Ctr, Aging & Dementia Res Ctr, Dept Psychiat, New York, NY 10016 USA

[3] NYU, Med Ctr, Aging & Dementia Res Ctr, Dept Pathol, New York, NY 10016 USA

来源：

BRAIN RESEARCH | 1998年 / 799卷 / 01期

关键词：

Alzheimer disease; neurofibrillary pathology; neurofibrillary staging; hippocampus; stereology;

D O I：

10.1016/S0006-8993(98)00441-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyrus of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：156 / 158

页数：3

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