Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans:: a case of good vs. bad lipids?

被引：111

作者：

Russell, AP

Gastaldi, G

Bobbioni-Harsch, E

Arboit, P

Gobelet, C

Dériaz, O

Golay, A

Witztum, JL

Giacobinob, JP

机构：

[1] Clin Romande Readaptat SUVA Care, CH-1951 Sion, Switzerland

[2] Univ Geneva, Med Ctr, Dept Biochem Med, CH-1211 Geneva 4, Switzerland

[3] Univ Hosp Geneva, Div Therapeut Educ Chron Dis, Geneva, Switzerland

[4] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

FEBS LETTERS | 2003年 / 551卷 / 1-3期

关键词：

lipid peroxidation; muscle; obesity; endurance training; 4-hydroxynonenal; intra-myocellular triglyceride;

D O I：

10.1016/S0014-5793(03)00875-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：104 / 106

页数：3

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