Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate

被引：238

作者：

Paschka, AG

Butler, R

Young, CYF

机构：

[1] Mayo Clin & Mayo Fdn, Dept Urol, Rochester, MN 55905 USA

[2] Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

来源：

CANCER LETTERS | 1998年 / 130卷 / 1-2期

关键词：

green tea; apoptosis; prostate cancer;

D O I：

10.1016/S0304-3835(98)00084-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Green tea components exert many biological effects, including antitumor and cancer preventive activities. In the search for anticancer agents for prostate cancer the inhibitory effects of green tea components were tested on the prostate cancer cell lines LNCaP, PC-3 and DU145. (-)-Epigatlocatechin-3-gallate (EGCG) proved to be the most potent catechin at inhibiting cell growth. The inhibition induced by EGCG was found to occur via apoptotic cell death as shown by changes in nuclear morphology and DNA fragmentation. Thus, we report the first evidence that EGCG is the active component in green tea and induces apoptosis in human prostate cancer cells. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 7

页数：7

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