Ferrous and ferric iron accumulates in the brain of aged Long-Evans Cinnamon rats, an animal model of Wilson's disease

被引：22

作者：

Kim, JM

Ko, SB

Kwon, SJ

Kim, HJ

Han, MK

Kim, DW

Cho, SS

Jeon, BS

机构：

[1] Seoul Natl Univ, Dept Neurol, Coll Med, Seoul Natl Univ Hosp,Clin Res Inst, Seoul 110744, South Korea

[2] Seoul Natl Univ, Bundang Hosp, Dept Neurol, Seoul 151, South Korea

[3] Seoul Natl Univ, Coll Med,Clin Res Inst, Dept Anat, Seoul Natl Univ Hosp, Seoul 110744, South Korea

来源：

NEUROSCIENCE LETTERS | 2005年 / 382卷 / 1-2期

关键词：

Long-Evans cinnamon rat; Wilson's disease; copper; iron; ferrous iron; ferric iron;

D O I：

10.1016/j.neulet.2005.03.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Long-Evans Cinnamon (LEC) rat, which accumulates excess copper (Cu) in its liver, is an animal model of Wilson's disease. We evaluated and compared the distributions of Cu, ferrous (Fe2+), and ferric (Fe3+) iron in four-brain regions, namely, in the cerebral cortex, cerebellum, substantia nigra (SN), and striatum of LEC and Long-Evans Agouti rats at 30 and 55 weeks. Cu levels were elevated in the striatum of LEC rats, and Fe2+ and Fe3+ were higher in the striatum and SN of LEC rats. Ratios of Fe2+ to Fe3+ were > 1 in four regions, and were highest in the striatum and SN of LEC rats. Cu and iron levels were found to be augmented during aging, and we suggest that these accumulations may exert deleterious effects in aged LEC rats. This study is the first report that demonstrates regional differences of Fe2+ and Fe3+ accumulation in the brain of aged LEC rats. Further studies are required to elucidate the mechanisms of Cu and iron accumulations and of their effects. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：143 / 147

页数：5

共 25 条

[1] THE WILSON DISEASE GENE IS A PUTATIVE COPPER TRANSPORTING P-TYPE ATPASE SIMILAR TO THE MENKES GENE [J].