Endothelin receptor antagonists: Synthesis and structure-activity relationships of substituted benzothiazine-1,1-dioxides

被引：17

作者：

Berryman, KA

Edmunds, JJ

Bunker, AM

Haleen, S

Bryant, J

Welch, KM

Doherty, AM

机构：

[1] Warner Lambert Co, Parke Davis Pharmaceut Res, Dept Chem, Ann Arbor, MI 48105 USA

[2] Warner Lambert Co, Parke Davis Pharmaceut Res, Dept Therapeut, Ann Arbor, MI 48105 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 09期

关键词：

D O I：

10.1016/S0968-0896(98)00080-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of benzothiazine-1,1-dioxide derivatives as a new structural class of potent endothelin receptor antagonists is described. Structure-activity relationships (SAR) revealed that PD164800 (1) is a potent antagonist of the ETA receptor subtype. (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：1447 / 1456

页数：10

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