Type I interferon as a link between innate and adaptive immunity through dendritic cell stimulation

被引：149

作者：

Tough, DF ^{[1
]}

机构：

[1] Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks, England

来源：

LEUKEMIA & LYMPHOMA | 2004年 / 45卷 / 02期

关键词：

type I interferon; dendritic cell; natural interferon producing cell;

D O I：

10.1080/1042819031000149368

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Type I interferon (IFN-alpha/beta) is expressed rapidly after infection and plays a key role in innate defense against pathogens. Recent studies have shown that a connection exists between IFN-alpha/beta and antigen-presenting dendritic cells (DCs) at two levels. Firstly, a specific DC precursor, the plasmacytoid pre-DC (p-preDC), was identified as a cell type able to secrete very high amounts of IFN-alpha/beta following stimulation with infectious agents. Secondly, IFN-alpha/beta has been shown to act as a differentiation/maturation factor for DCs. These findings will be discussed in association with evidence indicating that IFN-alpha/beta can enhance and modulate immune responses in vivo . Taken together, the available data suggest that IFN-alpha/beta serves as a link between the innate response to infection and the adaptive immune response.

引用

页码：257 / 264

页数：8

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