Asymmetric synthesis of anti-convulsive drug (S)-Vigabatrin®

被引：27

作者：

Chandrasekhar, S ^{[1
]}

Mohapatra, S ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(98)01324-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric synthesis of fully protected (S) - Vigabatrin(R) is described using Sharpless asymmetric aminohydroxylation and reductive elimination of alpha-oxy-beta-amino carbonylhydrazone as key steps. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：6415 / 6418

页数：4

共 27 条

[1] Enantioselective synthesis of (S)-Vigabatrin(R)
Alcon, M
Poch, M
Moyano, A
Pericas, MA
Riera, A
[J]. TETRAHEDRON-ASYMMETRY, 1997, 8 (17) : 2967 - 2974
[2] BAXTER CF, 1958, J BIOL CHEM, V233, P1135
[3] A mild amide to carbamate transformation
Burk, MJ
Allen, JG
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (20) : 7054 - 7057
[4] VIGABATRIN SYNTHESIS BY THERMAL REARRANGEMENTS
CASARA, P
[J]. TETRAHEDRON LETTERS, 1994, 35 (19) : 3049 - 3050
[5] Neighbouring group assisted sulfonamide cleavage of sharpless aminols under acetonation conditions
Chandrasekhar, S
Mohapatra, S
[J]. TETRAHEDRON LETTERS, 1998, 39 (07) : 695 - 698
[6] Chandrasekhar S, 1996, SYNLETT, P759
[7] Deprotection of mono and dimethoxy phenyl methyl ethers using catalytic amounts of DDQ
Chandrasekhar, S
Sumithra, G
Yadav, JS
[J]. TETRAHEDRON LETTERS, 1996, 37 (10) : 1645 - 1646
[8] DELGADOESCUETA AV, 1986, BASIC MECH EPILEPSIE, P365
[9] Enna S. J., 1983, GABA RECEPTORS
[10] KNOWN TW, 1992, J ORG CHEM, V57, P6169

← 1 2 3 →