The psammaplysenes, specific inhibitors of FOXO1a nuclear export

被引：49

作者：

Schroeder, FC

Kau, TR

Silver, PA

Clardy, J ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 04期

关键词：

D O I：

10.1021/np049624z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A small collection of marine natural product extracts was screened for compounds that would compensate lost tumor suppressor functionality in PTEN-deficient cells. From the most active extract, the previously unreported bromotyrosine derivative, psammaplysene A (1), was identified. Psammaplysene A compensates for PTEN loss by relocalizing the transcription factor FOXO1a to the nucleus.

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页码：574 / 576

页数：3

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