Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci

被引：285

作者：

Cookson, WOCM ^{[1
]}

Ubhi, B

Lawrence, R

Abecasis, GR

Walley, AJ

Cox, HE

Coleman, R

Leaves, NI

Trembath, RC

Moffatt, MF

Harper, JI

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England

[2] Great Ormond St Hosp Sick Children, London WC1N 3JH, England

[3] Inst Child Hlth, London, England

[4] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England

来源：

NATURE GENETICS | 2001年 / 27卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/86867

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.

引用

页码：372 / 373

页数：2

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