Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression

被引：285

作者：

Uhr, Manfred ^{[1
]}

Tontsch, Alina ^{[1
]}

Namendorf, Christian ^{[1
]}

Ripke, Stephan ^{[1
]}

Lucae, Susanne ^{[1
]}

Ising, Marcus ^{[1
]}

Dose, Tatjana ^{[1
]}

Ebinger, Martin ^{[1
]}

Rosenhagen, Marcus ^{[1
]}

Kohli, Martin ^{[1
]}

Kloiber, Stefan ^{[1
]}

Salyakina, Daria ^{[1
]}

Bettecken, Thomas ^{[1
]}

Specht, Michael ^{[1
]}

Puetz, Benno ^{[1
]}

Binder, Elisabeth B. ^{[1
]}

Mueller-Myhsok, Bertram ^{[1
]}

Holsboer, Florian ^{[1
]}

机构：

[1] Max Planck Inst Psychiat, D-80804 Munich, Germany

来源：

NEURON | 2008年 / 57卷 / 02期

关键词：

D O I：

10.1016/j.neuron.2007.11.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The clinical efficacy of a systemically administered drug acting on the central nervous system depends on its ability to pass the blood-brain barrier, which is regulated by transporter molecules such as ABCB1 (MDR1). Here we report that polymorphisms in the ABCB1 gene predict the response to antidepressant treatment in those depressed patients receiving drugs that have been identified as substrates of ABCB1 using abcb1ab double-knockout mice. Our results indicate that the combined consideration of both the medication's capacity to act as an ABCB1-transporter substrate and the patient's ABCB1 genotype are strong predictors for achieving a remission. This finding can be viewed as a further step into personalized antidepressant treatment.

引用

页码：203 / 209

页数：7

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