Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells

被引：100

作者：

Zecchini, V

Domaschenz, R

Winton, D

Jones, P ^{[1
]}

机构：

[1] MRC, Canc Cell Unit, Hutchison MRC Res Ctr, Cambridge CB2 2XZ, England

[2] Univ Cambridge, Canc Res UK, Dept Oncol, Med Res Inst, Cambridge CB2 2XY, England

来源：

GENES & DEVELOPMENT | 2005年 / 19卷 / 14期

关键词：

Goblet cell; Hes5; Hes1;

D O I：

10.1101/gad.341705

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The intestinal epithelium comprises differentiated cells of four lineages maintained by precursor cells. As the Notch pathway controls the fate of proliferating cells in many systems, we investigated the effect of conditional expression of an activated Notch mutant in intestinal epithelium. An increase in the number of goblet cells occurs within 8 h of induction, due to an effect of Notch on post-mitotic cells, not on precursors. This observation broadens the role of Notch into controlling postmitotic differentiation and indicates that the composition of the epithelium is not solely determined by progenitor cells.

引用

收藏

页码：1686 / 1691

页数：6

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