共 44 条
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy
被引:436
作者:

Pereyra, Florencia
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA
Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Addo, Marylyn M.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Kaufmann, Daniel E.
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h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Liu, Yang
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h-index: 0
机构:
Monogram Biosci, San Francisco, CA USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Miura, Toshiyuki
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h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Rathod, Almas
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h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Baker, Brett
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h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Trocha, Alicja
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h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA
Howard Hughes Med Inst, Chevy Chase, MD USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Rosenberg, Rachel
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h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Mackey, Elizabeth
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h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Ueda, Peggy
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h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Lu, Zhigang
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h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Cohen, Daniel
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h-index: 0
机构:
Fenway Community Hlth Care Ctr, Boston, MA USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Wrin, Terri
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h-index: 0
机构:
Monogram Biosci, San Francisco, CA USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Petropoulos, Christos J.
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h-index: 0
机构:
Monogram Biosci, San Francisco, CA USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Rosenberg, Eric S.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

Walker, Bruce D.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA
Howard Hughes Med Inst, Chevy Chase, MD USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
机构:
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA
[2] Harvard Univ, Sch Med, Div Aids, Boston, MA 02129 USA
[3] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA
[4] Fenway Community Hlth Care Ctr, Boston, MA USA
[5] Howard Hughes Med Inst, Chevy Chase, MD USA
[6] Monogram Biosci, San Francisco, CA USA
关键词:
D O I:
10.1086/526786
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Background. Spontaneous control of human immunodeficiency virus (HIV) infection has been documented in a minority of HIV-infected individuals. The mechanisms behind this outcome remain largely unknown, and a better understanding of them will likely influence future vaccine strategies. Methods. HIV-specific T cell and antibody responses as well as host genetics were examined in untreated HIV-infected patients who maintain comparatively low plasma HIV RNA levels (hereafter, controllers), including those with levels of < 50 RNA copies/mL (elite controllers, n = 64), those with levels of 50-2000 copies/mL (viremic controllers, n = 60); we also examined HIV-specific T cell and antibody responses as well as host genetics for patients with levels of > 10,000 copies/mL (chronic progressors, n = 30). Results. CD8 + T cells from both controller groups preferentially target Gag over other proteins in the context of diverse HLA class I alleles, whereas responses are more broadly distributed in persons with progressive infection. Elite controllers represent a distinct group of individuals who have significantly more CD4 and CD8 T cells that secrete interferon-gamma and interleukin-2 and lower levels of HIV-neutralizing antibodies. Individual responses were quite heterogeneous, and none of the parameters evaluated was uniquely associated with the ability to control viremia. Conclusions. Elite controllers are a distinct group, even when compared to persons with low level viremia, but they exhibit marked genetic and immunologic heterogeneity. Even low-level viremia among HIV controllers was associated with measurable T cell dysfunction, which has implications for current prophylactic vaccine strategies.
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收藏
页码:563 / 571
页数:9
相关论文
共 44 条
[1]
Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load
[J].
Addo, MM
;
Yu, XG
;
Rathod, A
;
Cohen, D
;
Eldridge, RL
;
Strick, D
;
Johnston, MN
;
Corcoran, C
;
Wurcel, AG
;
Fitzpatrick, CA
;
Feeney, ME
;
Rodriguez, WR
;
Basgoz, N
;
Draenert, R
;
Stone, DR
;
Brander, C
;
Goulder, PJR
;
Rosenberg, ES
;
Altfeld, M
;
Walker, BD
.
JOURNAL OF VIROLOGY,
2003, 77 (03)
:2081-2092

Addo, MM
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Yu, XG
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Rathod, A
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Cohen, D
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Eldridge, RL
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Strick, D
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Johnston, MN
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Corcoran, C
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Wurcel, AG
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Fitzpatrick, CA
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Feeney, ME
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Rodriguez, WR
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Basgoz, N
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Draenert, R
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Stone, DR
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Brander, C
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Goulder, PJR
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Rosenberg, ES
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Altfeld, M
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

Walker, BD
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA
[2]
CCR2-64I allele and genotype association with delayed AIDS progression in African women
[J].
Anzala, AO
;
Ball, TB
;
Rostron, T
;
O'Brien, SJ
;
Plummer, FA
;
Rowland-Jones, SL
.
LANCET,
1998, 351 (9116)
:1632-1633

Anzala, AO
论文数: 0 引用数: 0
h-index: 0
机构: John Radcliffe Hosp, Inst Mol Med, Mol Immunol Grp, Oxford OX3 9DU, England

Ball, TB
论文数: 0 引用数: 0
h-index: 0
机构: John Radcliffe Hosp, Inst Mol Med, Mol Immunol Grp, Oxford OX3 9DU, England

Rostron, T
论文数: 0 引用数: 0
h-index: 0
机构: John Radcliffe Hosp, Inst Mol Med, Mol Immunol Grp, Oxford OX3 9DU, England

O'Brien, SJ
论文数: 0 引用数: 0
h-index: 0
机构: John Radcliffe Hosp, Inst Mol Med, Mol Immunol Grp, Oxford OX3 9DU, England

Plummer, FA
论文数: 0 引用数: 0
h-index: 0
机构: John Radcliffe Hosp, Inst Mol Med, Mol Immunol Grp, Oxford OX3 9DU, England

Rowland-Jones, SL
论文数: 0 引用数: 0
h-index: 0
机构:
John Radcliffe Hosp, Inst Mol Med, Mol Immunol Grp, Oxford OX3 9DU, England John Radcliffe Hosp, Inst Mol Med, Mol Immunol Grp, Oxford OX3 9DU, England
[3]
Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations
[J].
Bailey, Justin R.
;
Williams, Thomas M.
;
Siliciano, Robert F.
;
Blankson, Joel N.
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2006, 203 (05)
:1357-1369

Bailey, Justin R.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21287 USA

Williams, Thomas M.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21287 USA

Siliciano, Robert F.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21287 USA

Blankson, Joel N.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21287 USA Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21287 USA
[4]
Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy
[J].
Bailey, Justin R.
;
Lassen, Kara G.
;
Yang, Hung-Chih
;
Quinn, Thomas C.
;
Ray, Stuart C.
;
Blankson, Joel N.
;
Siliciano, Robert F.
.
JOURNAL OF VIROLOGY,
2006, 80 (10)
:4758-4770

Bailey, Justin R.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

Lassen, Kara G.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

Yang, Hung-Chih
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

Quinn, Thomas C.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

Ray, Stuart C.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

Blankson, Joel N.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

Siliciano, Robert F.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
[5]
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
[J].
Betts, Michael R.
;
Nason, Martha C.
;
West, Sadie M.
;
De Rosa, Stephen C.
;
Migueles, Stephen A.
;
Abraham, Jonathan
;
Lederman, Michael M.
;
Benito, Jose M.
;
Goepfert, Paul A.
;
Connors, Mark
;
Roederer, Mario
;
Koup, Richard A.
.
BLOOD,
2006, 107 (12)
:4781-4789

Betts, Michael R.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Nason, Martha C.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

West, Sadie M.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

De Rosa, Stephen C.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Migueles, Stephen A.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Abraham, Jonathan
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Lederman, Michael M.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Benito, Jose M.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Goepfert, Paul A.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Connors, Mark
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Roederer, Mario
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Koup, Richard A.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA
[6]
Analysis of total human immunodeficiency virus (HIV)-specific CD4+ and CD8+ T-cell responses:: Relationship to viral load in untreated HIV infection
[J].
Betts, MR
;
Ambrozak, DR
;
Douek, DC
;
Bonhoeffer, S
;
Brenchley, JM
;
Casazza, JP
;
Koup, RA
;
Picker, LJ
.
JOURNAL OF VIROLOGY,
2001, 75 (24)
:11983-11991

Betts, MR
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Portland, OR 97201 USA

Ambrozak, DR
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Portland, OR 97201 USA

Douek, DC
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Portland, OR 97201 USA

Bonhoeffer, S
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Portland, OR 97201 USA

Brenchley, JM
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Portland, OR 97201 USA

Casazza, JP
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Portland, OR 97201 USA

Koup, RA
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Portland, OR 97201 USA

Picker, LJ
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Portland, OR 97201 USA
[7]
LONG-TERM HIV-1 INFECTION WITHOUT IMMUNOLOGICAL PROGRESSION
[J].
BUCHBINDER, SP
;
KATZ, MH
;
HESSOL, NA
;
OMALLEY, PM
;
HOLMBERG, SD
.
AIDS,
1994, 8 (08)
:1123-1128

BUCHBINDER, SP
论文数: 0 引用数: 0
h-index: 0
机构:
CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV HIV AIDS, ATLANTA, GA 30341 USA CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV HIV AIDS, ATLANTA, GA 30341 USA

KATZ, MH
论文数: 0 引用数: 0
h-index: 0
机构:
CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV HIV AIDS, ATLANTA, GA 30341 USA CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV HIV AIDS, ATLANTA, GA 30341 USA

HESSOL, NA
论文数: 0 引用数: 0
h-index: 0
机构:
CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV HIV AIDS, ATLANTA, GA 30341 USA CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV HIV AIDS, ATLANTA, GA 30341 USA

OMALLEY, PM
论文数: 0 引用数: 0
h-index: 0
机构:
CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV HIV AIDS, ATLANTA, GA 30341 USA CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV HIV AIDS, ATLANTA, GA 30341 USA

HOLMBERG, SD
论文数: 0 引用数: 0
h-index: 0
机构:
CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV HIV AIDS, ATLANTA, GA 30341 USA CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV HIV AIDS, ATLANTA, GA 30341 USA
[8]
VIROLOGICAL AND IMMUNOLOGICAL CHARACTERIZATION OF LONG-TERM SURVIVORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION
[J].
CAO, YZ
;
QIN, LM
;
ZHANG, LQ
;
SAFRIT, J
;
HO, DD
.
NEW ENGLAND JOURNAL OF MEDICINE,
1995, 332 (04)
:201-208

CAO, YZ
论文数: 0 引用数: 0
h-index: 0
机构:
NYU,SCH MED,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016 NYU,SCH MED,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

QIN, LM
论文数: 0 引用数: 0
h-index: 0
机构:
NYU,SCH MED,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016 NYU,SCH MED,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

ZHANG, LQ
论文数: 0 引用数: 0
h-index: 0
机构:
NYU,SCH MED,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016 NYU,SCH MED,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

SAFRIT, J
论文数: 0 引用数: 0
h-index: 0
机构:
NYU,SCH MED,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016 NYU,SCH MED,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

HO, DD
论文数: 0 引用数: 0
h-index: 0
机构:
NYU,SCH MED,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016 NYU,SCH MED,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016
[9]
HLA and HIV-1:: Heterozygote advantage and B*35-Cw*04 disadvantage
[J].
Carrington, M
;
Nelson, GW
;
Martin, MP
;
Kissner, T
;
Vlahov, D
;
Goedert, JJ
;
Kaslow, R
;
Buchbinder, S
;
Hoots, K
;
O'Brien, SJ
.
SCIENCE,
1999, 283 (5408)
:1748-1752

Carrington, M
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Genom Divers, Frederick, MD 21702 USA

Nelson, GW
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Genom Divers, Frederick, MD 21702 USA

Martin, MP
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Genom Divers, Frederick, MD 21702 USA

Kissner, T
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Genom Divers, Frederick, MD 21702 USA

Vlahov, D
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Genom Divers, Frederick, MD 21702 USA

Goedert, JJ
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Genom Divers, Frederick, MD 21702 USA

Kaslow, R
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Genom Divers, Frederick, MD 21702 USA

Buchbinder, S
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Genom Divers, Frederick, MD 21702 USA

Hoots, K
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Lab Genom Divers, Frederick, MD 21702 USA

O'Brien, SJ
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机构:
NCI, Lab Genom Divers, Frederick, MD 21702 USA NCI, Lab Genom Divers, Frederick, MD 21702 USA
[10]
HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5
[J].
Dragic, T
;
Litwin, V
;
Allaway, GP
;
Martin, SR
;
Huang, YX
;
Nagashima, KA
;
Cayanan, C
;
Maddon, PJ
;
Koup, RA
;
Moore, JP
;
Paxton, WA
.
NATURE,
1996, 381 (6584)
:667-673

Dragic, T
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机构: ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Litwin, V
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机构: ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Allaway, GP
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机构: ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Martin, SR
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机构: ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Huang, YX
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机构: ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Nagashima, KA
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机构: ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Cayanan, C
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机构: ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Maddon, PJ
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机构: ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Koup, RA
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机构: ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Moore, JP
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机构: ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Paxton, WA
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机构: ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016