Aging Affects Human B Cell Responses

被引：113

作者：

Frasca, Daniela ^{[1
]}

Blomberg, Bonnie B. ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Microbiol & Immunol, Miami, FL 33101 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2011年 / 31卷 / 03期

关键词：

Aging; B cells; immunoglobulin class switch; vaccination; CLASS-SWITCH RECOMBINATION; INDUCED CYTIDINE DEAMINASE; AGE-RELATED-CHANGES; HYPER-IGM SYNDROME; INFLUENZA VACCINATION; IMMUNE-SYSTEM; T-CELLS; OLD-AGE; SOMATIC HYPERMUTATION; ANTIBODY-RESPONSES;

D O I：

10.1007/s10875-010-9501-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.

引用

页码：430 / 435

页数：6

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