Cerebrospinal fluid concentrations of quinupristin-dalfopristin in a patient with vancomycin-resistant Enterococcus faecalis ventriculitis

被引：22

作者：

Garey, KW

Tesoro, E

Muggia, V

Pasquier, O

Rodvold, KA

机构：

[1] Univ Illinois, Coll Pharm, Chicago, IL 60612 USA

[2] Aventis Pharma, Antony, France

来源：

PHARMACOTHERAPY | 2001年 / 21卷 / 06期

关键词：

D O I：

10.1592/phco.21.7.748.34573

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A 44-year-old man was treated successfully for vancomycin-resistant Enterococcus faecium (VREF) ventriculitis with intrathecal quinupristin-dalfopristin I mg, 2 mg, and 4 mg, and other intravenous antibiotics. Cerebrospinal fluid samples were collected before and after the 1-mg and 2-mg, doses to determine the concentrations of quinupristin-dalfopristin and its active metabolites. Concentrations were above the minimum inhibitory concentration for VREF immediately after unclamping the extraventricular drain and were quantifiable for at least 7 hours.

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页码：748 / 750

页数：3

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