1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) induces apoptosis in human neuroblastoma cell lines

被引：8

作者：

Akundi, RS ^{[1
]}

Hüll, M ^{[1
]}

Clement, HW ^{[1
]}

Fiebich, BL ^{[1
]}

机构：

[1] Univ Freiburg, Sch Med, Dept Psychiat, Neurochem Lab, D-79104 Freiburg, Germany

来源：

APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS | 2003年 / 1010卷

关键词：

TaClo; Parkinson's disease; caspase-3; neuroblastoma; apoptosis;

D O I：

10.1196/annals.1299.053

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The former popular hypnotic chloral hydrate has been known to spontaneously condense with tryptamine in the body to give rise to a highly unpolar 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) derivative. Earlier studies have revealed the relative permeability of the molecule through the body, and its ability to induce Parkinson-like symptoms in rats. In this study, we report that TaClo is a highly cytotoxic agent that leads to apoptosis in human neuroblastoma cells involving caspase-3 activation.

引用

页码：304 / 306

页数：3

共 5 条

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