Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

被引：661

作者：

Calkin, Anna C. ^{[1
]}

Tontonoz, Peter ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 04期

基金：

美国国家卫生研究院;

关键词：

LIVER-X-RECEPTOR; BINDING CASSETTE TRANSPORTER; PERIPHERAL INSULIN SENSITIVITY; CELLULAR CHOLESTEROL EFFLUX; TYPE-2; DIABETES-MELLITUS; DIET-INDUCED OBESITY; BILE-ACID; FATTY-ACID; GENE-EXPRESSION; ADIPOSE-TISSUE;

D O I：

10.1038/nrm3312

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Nuclear receptors are integrators of hormonal and nutritional signals, mediating changes to metabolic pathways within the body. Given that modulation of lipid and glucose metabolism has been linked to diseases including type 2 diabetes, obesity and atherosclerosis, a greater understanding of pathways that regulate metabolism in physiology and disease is crucial. The liver X receptors (LXRs) and the farnesoid X receptors (FXRs) are activated by oxysterols and bile acids, respectively. Mounting evidence indicates that these nuclear receptors have essential roles, not only in the regulation of cholesterol and bile acid metabolism but also in the integration of sterol, fatty acid and glucose metabolism.

引用

页码：213 / 224

页数：12

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