学术探索
学术期刊
新闻热点
数据分析
智能评审

Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency

被引：38
作者：
Kottlors, M
Jaksch, M
Ketelsen, UP
Weiner, S
Glocker, FX
Lücking, CH
机构：
[1] Univ Freiburg, Neurol Klin, Neurozentrum, Dept Neurol, D-79106 Freiburg, Germany
[2] Acad Hosp Munchen Schwabing, Stoffwechselzentrum Munchen Schwabing, Inst Klin Chem Mol Diagnost & Mitochondriale Gene, D-80804 Munich, Germany
[3] Childrens Hosp, dept Neuropediat & Muscular Dis, D-79106 Freiburg, Germany
[4] Univ Freiburg, Dept Med, D-79106 Freiburg, Germany
来源：
NEUROMUSCULAR DISORDERS | 2001年 / 11卷 / 08期
关键词：
carnitine; carnitine palmitoyltransferase deficiency; rhabdomyolysis; valproic acid;
D O I：
10.1016/S0960-8966(01)00228-0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A 47-year-old man suffering from a bipolar disorder and intermittent myoglobinuria presented with acute rhabdomyolysis with renal failure after starting therapy with valproic acid. On morphological examination, skeletal muscle revealed increased lipid storage. Biochemically, decreased enzyme activity of carnitine palmitoyltransferase (CPT) type II with carnitine levels in the lower limit was found. Genetic analysis detected the common Ser113Leu substitution on one allele of the CPT2 gene. We conclude that valproic acid should be avoided in patients with CPT type II deficiency. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：757 / 759
页数：3
相关论文
共 14 条
12