Peptide nucleic acid synthesis by novel amide formation

被引：37

作者：

Lee, Hyunil ^{[1
]}

Jeon, Jae Hoon ^{[1
]}

Lim, Jong Chan ^{[1
]}

Choi, Hoon ^{[1
]}

Yoon, Yeohong ^{[1
]}

Kim, Sung Kee ^{[1
]}

机构：

[1] PANAGENE INC, Taejon 305345, South Korea

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 17期

关键词：

D O I：

10.1021/ol071215h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of self-activated peptide nucleic acid (PNA) monomers and an efficient method for PNA synthesis using a benzothiazole-2-sulfonyl (Bts) group as an amine-protecting group as well as an acid-activating group are reported. Couplings were complete within 120 min, and the deprotection was performed in 10 min. This Bts strategy provides a high purity PNA oligomer and is appropriate for large-scale synthesis. The results of the 15-mer PNA oligomer are described.

引用

页码：3291 / 3293

页数：3

共 18 条

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[2]

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[3]

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