Quercetin: A potential drug to reverse multidrug resistance

被引:196
作者
Chen, Chen [1 ]
Zhou, Jane [2 ]
Ji, Chunyan [1 ]
机构
[1] Shandong Univ, Dept Hematol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China
[2] Zenith Diagnost Consultants, Redding, CA 96001 USA
关键词
Quercetin; Multidrug resistance; P-glycoprotein; Multidrug resistance associated protein; Breast cancer resistance protein; CORONARY-HEART-DISEASE; DIETARY FLAVONOID GLYCOSIDES; VITRO ANTILEUKEMIC ACTIVITY; P-GLYCOPROTEIN; LUNG-CANCER; CELL-LINE; TRANSPORT; INHIBITION; PHARMACOKINETICS; PROTEIN;
D O I
10.1016/j.lfs.2010.07.004
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This review centers on recent findings with respect to modulating cancer multidrug resistance (MDR) with the well-known flavonoid quercetin. After a short introduction of quercetin, major in vitro and in vivo findings are summarized showing that quercetin is a MDR modulator and thus a potential chemosensitizer. Finally, we contemplate future prospects of modulating MDR in the clinic. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:333 / 338
页数:6
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