Practical syntheses of antiviral nucleosides

被引：18

作者：

Izawa, K ^{[1
]}

Shiragami, H ^{[1
]}

机构：

[1] Ajinomoto Co Inc, Cent Res Labs, Kawasaki, Kanagawa 210, Japan

来源：

PURE AND APPLIED CHEMISTRY | 1998年 / 70卷 / 02期

关键词：

D O I：

10.1351/pac199870020313

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Guanosine produced by fermentation is one of the nucleosides most readily available on an industrial scale. We have recently developed several processes leading to known antiviral agents starting with guanosine. The processes involve enzymatic transglycosylation for stavudine (d4T), chemical transpurination for acyclovir and ganciclovir, and novel alkylation for penciclovir and famciclovir.

引用

页码：313 / 318

页数：6

共 37 条

[1]

AMINO Y, 1991, CHEM PHARM BULL, V39, P622

[2] A DIRECT METHOD FOR THE PREPARATION OF 2-HYDROXYETHOXYMETHYL DERIVATIVES OF GUANINE, ADENINE, AND CYTOSINE [J].

BARRIO, JR ;

BRYANT, JD ;

KEYSER, GE .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (05) :572-574

[3] TRANSGLYCOSYLATION OF GUANINE NUCLEOSIDES [J].

BORYSKI, J ;

GOLANKIEWICZ, B .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1987, 6 (1-2) :385-386

[4] APPLICATION OF THE TRANSPURINATION REACTION TO SYNTHESIS OF ACYCLIC GUANOSINE ANALOGS [J].

BORYSKI, J ;

GOLANKIEWICZ, B .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1989, 8 (04) :529-536

[5] PREPARATION OF XANTHINE-3-ACETIC ACID AND SOME DERIVATIVES [J].

BRIDSON, PK ;

RICHMOND, G ;

YEH, F .

SYNTHETIC COMMUNICATIONS, 1990, 20 (16) :2459-2467

[6] PREPARATION AND PROPERTIES OF SOME BENZYLATED NUCLEOSIDES [J].

BROOKES, P ;

DIPPLE, A ;

LAWLEY, PD .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1968, (16) :2026-&

[7]

COSFORD NDP, 1994, NUCLEOS NUCLEOT, V13, P1011

[8] THE EFFECT OF THE C-6 SUBSTITUENT ON THE REGIOSELECTIVITY OF N-ALKYLATION OF 2-AMINOPURINES [J].

GEEN, GR ;

GRINTER, TJ ;

KINCEY, PM ;

JARVEST, RL .

TETRAHEDRON, 1990, 46 (19) :6903-6914

[9] PRODRUGS OF THE SELECTIVE ANTIHERPESVIRUS AGENT 9-[4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL]GUANINE (BRL 39123) WITH IMPROVED GASTROINTESTINAL ABSORPTION PROPERTIES [J].

HARNDEN, MR ;

JARVEST, RL ;

BOYD, MR ;

SUTTON, D ;

HODGE, RAV .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (08) :1738-1743

[10] SYNTHESIS AND ANTIVIRAL ACTIVITY OF 9-[4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL]PURINES [J].

HARNDEN, MR ;

JARVEST, RL ;

BACON, TH ;

BOYD, MR .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (09) :1636-1642

← 1 2 3 4 →