The MAGUK family protein CARD11 is essential for lymphocyte activation

被引：286

作者：

Hara, H

Wada, T

Bakal, C

Kozieradzki, I

Suzuki, S

Suzuki, N

Nghiem, M

Griffiths, EK

Krawczyk, C

Bauer, B

D'Acquisto, F

Ghosh, S

Yeh, WC

Baier, G

Rottapel, R

Penninger, JM

机构：

[1] Austrian Acad Sci, Inst Mol Biotechnol, A-1030 Vienna, Austria

[2] Univ Toronto, Ontario Canc Inst, Hlth Network, Toronto, ON M5G 2C1, Canada

[3] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2C1, Canada

[4] Univ Toronto, Dept Immunol, Toronto, ON M5G 2C1, Canada

[5] Univ Innsbruck, Inst Med Biol & Human Genet, A-6020 Innsbruck, Austria

[6] Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA

[7] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

IMMUNITY | 2003年 / 18卷 / 06期

关键词：

D O I：

10.1016/S1074-7613(03)00148-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Members of the MAGUK family proteins cluster receptors and intracellular signaling molecules at the neuronal synapse. We report that genetic inactivation of the MAGUK family protein CARD11/Carmal/Bimp3 results in a complete block in T and B cell immunity. CARD11 is essential for antigen receptor- and PKC-mediated proliferation and cytokine production in T and B cells due to a selective defect in JNK and NFkappaB activation. Moreover, B cell proliferation and JNK activation were impaired upon stimulation of TLR4 with lipopolysaccharide, indicating that CARD11 is involved in both the innate and adaptive immune systems. Our results show that the same family of molecules are critical regulators of neuronal synapses and immune receptor signaling.

引用

页码：763 / 775

页数：13

共 45 条

[1] Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b [J].