Treatment of stroke with marrow stromal cells

被引：1

作者：

Chopp, M ^{[1
]}

Li, Y ^{[1
]}

机构：

[1] Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI 48202 USA

来源：

MOLECULAR MECHANISMS AND EPOCHAL THERAPEUTICS OF ISCHEMIC STROKE AND DEMENTIA | 2003年 / 1252卷

关键词：

bone marrow stromal cells; stroke; neurotrophic factors; functional recovery; brain plasticity;

D O I：

10.1016/S0531-5131(03)00009-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We describe a method to treat neural injury from stroke using bone marrow stromal cells (MSCs) from humans and rodents. These cells, when injected intravenously into the rat or mouse, find their way to injured tissue, enter the tissue and evoke production of an array of neurotrophic factors. Highly significant reduction of neurological deficit results from this therapy as measured from a battery of neurological tests. The benefits of therapy persist for at least 3 months after treatment. Bone marrow cell therapy may show promise for the treatment of stroke, neural injury and neurodegenerative disease. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：465 / 470

页数：6

共 40 条

[1] Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury [J].

Abe, K .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2000, 20 (10) :1393-1408

[2] N-methyl-D-aspartate receptor-mediated increase of neurogenesis in adult rat dentate gyrus following stroke [J].

Arvidsson, A ;

Kokaia, Z ;

Lindvall, O .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 14 (01) :10-18

[3] Cell replacement therapies for central nervous system disorders [J].

Björklund, A ;

Lindvall, O .

NATURE NEUROSCIENCE, 2000, 3 (06) :537-544

[4] Cerebral ischemia and CNS transplantation: differential effects of grafted fetal rat striatal cells and human neurons derived from a clonal cell line [J].

Borlongan, CV ;

Tajima, Y ;

Trojanowski, J ;

Lee, VMY ;

Sanberg, PR .

NEUROREPORT, 1998, 9 (16) :3703-3709

[5]

CHEN J, 2003, IN PRESS STROKE

[6]

CHEN J, 2002, UNPUB INTRAVENOUS AD

[7] Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats [J].

Chen, JL ;

Li, Y ;

Wang, L ;

Zhang, ZG ;

Lu, DY ;

Lu, M ;

Chopp, M .

STROKE, 2001, 32 (04) :1005-1011

[8] Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats [J].

Chen, JL ;

Li, Y ;

Wang, L ;

Lu, M ;

Zhang, XH ;

Chopp, M .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2001, 189 (1-2) :49-57

[9]

Chen XG, 2002, STROKE, V33, P401

[10] Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: Growth factor production [J].

Chen, XG ;

Katakowski, M ;

Li, Y ;

Lu, DY ;

Wang, L ;

Zhang, LJ ;

Chen, JL ;

Xu, YX ;

Gautam, S ;

Mahmood, A ;

Chopp, M .

JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 69 (05) :687-691

← 1 2 3 4 →