Functional genomic analysis of cancer metastasis: biologic insights and clinical implications

被引：16

作者：

Kang, YB ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2005年 / 5卷 / 03期

关键词：

cancer; diagnosis; expression profiling; functional; genomics; metasis; mouse model; progenis;

D O I：

10.1586/14737159.5.3.385

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Metastasis, the spread of cancer from primary tumors to distant vital organs, has devastating consequences. Lack of effective tools to study this complex problem has hindered the development of accurate prognostic methods and effective treatments for metastatic cancer. In the postgenomic era, the application of genomic profiling methods to the analysis of clinical metastasis samples and animal metastasis models has revolutionized the field of metastasis research. This article reviews recent breakthroughs in the functional genomic analysis of metastasis. In addition, its impacts on our understanding of the molecular basis of metastasis and on clinical practice are discussed.

引用

页码：385 / 395

页数：11

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