Role of glucosamine in osteoarthritis

被引：12

作者：

Thakral, R. ^{[1
]}

Debnath, U. K. ^{[2
]}

Dent, C. ^{[3
]}

机构：

[1] Adelaide & Meath Hosp Inc, Natl Childrens Hosp, Dept Traumat & Orthopaed, Dublin 24, Ireland

[2] Univ Hosp Cardiff, Dept Traumat & Orthopaed, Cardiff CF14 4XW, Wales

[3] Univ Hosp Cardiff, Dept Orthopaed, Cardiff CF14 4XW, Wales

来源：

CURRENT ORTHOPAEDICS | 2007年 / 21卷 / 05期

关键词：

glucosamine; action; cartilage; arthritis;

D O I：

10.1016/j.cuor.2007.04.002

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Long-term follow-up studies on the effects of glucosamine preparations are stilt awaited. At present, only short-term results are available. They are known to relieve pain and decrease the rate of joint space narrowing clinically in osteoarthritis of knee, whilst the side effects are less when compared to the anti-inflammatory drugs and even placebos. It is probably safe - but there is no good evidence that it works. It would be ideal to have a medication that is a normal constituent of the human cartilage, which modifies the natural history of the disease. It is possible that long-term clinical studies with glucosamine may result in modifications to the indications for joint surgery or the time patients can live with osteoarthritis before developing substantial disability. (c) 2007 Published by Elsevier Ltd.

引用

页码：386 / 389

页数：4

共 34 条

[1]

Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy [J].

Anderson, JW ;

Nicolosi, RJ ;

Borzelleca, JF .

FOOD AND CHEMICAL TOXICOLOGY, 2005, 43 (02) :187-201

[2]

Baker CL, 2005, ORTHOPEDICS, V28, pS227

[3]

Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro [J].

Bassleer, C ;

Rovati, L ;

Franchimont, P .

OSTEOARTHRITIS AND CARTILAGE, 1998, 6 (06) :427-434

[4]

*BAZ LTD, 2005, EVED BASED HEALTHCAR, V9, P322

[5]

BRIFFA J, 1997, INT J ALT COMP MED, V15, P15

[6]

Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies [J].

Bruyere, O ;

Pavelka, K ;

Rovati, LC ;

Deroisy, R ;

Olejarova, M ;

Gatterova, J ;

Giacovelli, G ;

Reginster, JY .

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2004, 11 (02) :138-143

[7]

Chan PS, 2006, J RHEUMATOL, V33, P1329

[8]

Glucosamine for osteoarthritis: magic, hype, or confusion? It's probably safe-but there's no good evidence that it works [J].

Chard, J ;

Dieppe, P .

BMJ-BRITISH MEDICAL JOURNAL, 2001, 322 (7300) :1439-1440

[9]

Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes [J].

Dodge, GR ;

Jimenez, SA .

OSTEOARTHRITIS AND CARTILAGE, 2003, 11 (06) :424-432

[10]

HAMERMAN D, 1989, NEW ENGL J MED, V320, P1322

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