Biomimetic coatings on titanium:: a crystal growth study of octacalcium phosphate

被引:130
作者
Barrère, F
Layrolle, P
van Blitterswijk, CA
de Groot, K
机构
[1] IsoTis BV, NL-3723 MB Bilthoven, Netherlands
[2] Univ Twente, iBME, NL-7500 AE Enschede, Netherlands
[3] Leiden Univ, BRG, NL-2300 RA Leiden, Netherlands
关键词
D O I
10.1023/A:1011271713758
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The biomimetic approach allows the coating of metal implants with different calcium-phosphate (Ca-P) phases. Films elaborated at physiological conditions exhibited structures closely resembling those of bone mineral. For instance, octacalcium phosphate (OCP, Ca-8(HPO4)(2)(PO4)(4). 5H(2)O) crystals have been deposited on titanium through a two-step procedure. After cleaning and etching, Ti6Al4V plates were immersed for 24 h into a simulated body fluid (SBF1). A thin amorphous carbonated Ca-P layer precipitated on the metal substrate. Secondly, these thinly Ca-P coated titanium substrates were immersed for 48 h into another simulated body fluid (SBF2). The thin amorphous carbonated Ca-P layer induced the fast precipitation of a second Ca-P layer of 55 mum in thickness composed of OCP crystals. The measurements of Ca and P concentrations versus soaking time in SBF2 showed that the carbonated Ca-P layer partially dissolved before the deposition of the OCP coating. X-ray diffraction (XRD) revealed that OCP crystals grew epitaxially on the substrate. OCP is known to be one of the precursors during the bone mineralization process, thereby, this new generation of biomimetic coatings are promising for orthopedic surgery. (C) 2001 Kluwer Academic Publishers.
引用
收藏
页码:529 / 534
页数:6
相关论文
共 24 条
[1]  
Barrère F, 2000, MATER RES SOC SYMP P, V599, P135
[2]   Biomimetic calcium phosphate coatings on Ti6Al4V:: A crystal growth study of octacalcium phosphate and inhibition by Mg2+ and HCO3- [J].
Barrère, F ;
Layrolle, P ;
Van Blitterswijk, CA ;
De Groot, K .
BONE, 1999, 25 (02) :107S-111S
[3]  
BROWN WE, 1962, NATURE, V196, P1048, DOI 10.1038/1961048b0
[4]   SOLUTION CA/P RATIO AFFECTS CALCIUM-PHOSPHATE CRYSTAL PHASES [J].
CHENG, PT ;
PRITZKER, KPH .
CALCIFIED TISSUE INTERNATIONAL, 1983, 35 (4-5) :596-601
[5]   MATURATION OF CRYSTALLINE CALCIUM PHOSPHATES IN AQUEOUS SUSPENSIONS AT PHYSIOLOGIC PH [J].
EANES, ED ;
MEYER, JL .
CALCIFIED TISSUE RESEARCH, 1977, 23 (03) :259-269
[6]   OCTACALCIUM PHOSPHATE .3. INFRARED AND RAMAN VIBRATIONAL-SPECTRA [J].
FOWLER, BO ;
MARKOVIC, M ;
BROWN, WE .
CHEMISTRY OF MATERIALS, 1993, 5 (10) :1417-1423
[7]   6-YEAR RESULTS OF HYDROXYAPATITE-COATED TOTAL HIP-REPLACEMENT [J].
GEESINK, RGT ;
HOEFNAGELS, NHM .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 1995, 77B (04) :534-547
[8]   KINETICS OF CRYSTALLIZATION OF OCTACALCIUM PHOSPHATE [J].
HEUGHEBAERT, JC ;
NANCOLLAS, GH .
JOURNAL OF PHYSICAL CHEMISTRY, 1984, 88 (12) :2478-2481
[9]   PRECIPITATION OF OCTACALCIUM PHOSPHATE AT 37-DEGREES-C AND AT PH 7.4 - IN RELATION TO ENAMEL FORMATION [J].
IIJIMA, M ;
KAMEMIZU, H ;
WAKAMATSU, N ;
GOTO, T ;
DOI, Y ;
MORIWAKI, Y .
JOURNAL OF CRYSTAL GROWTH, 1991, 112 (2-3) :467-473
[10]  
*JOINT COM POWD DI, 1992, 261056 OCP JOINT COM