Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers

被引：139

作者：

Hentati, A

Ouahchi, K

Pericak-Vance, MA

Nijhawan, D

Ahmad, A

Yang, Y

Rimmler, J

Hung, WY

Schlotter, B

Ahmed, A

Ben Hamida, M

Hentati, F

Siddique, T

机构：

[1] Northwestern Univ, Sch Med, Chicago, IL 60611 USA

[2] Duke Univ, Ctr Med, Durham, England

[3] Civil Hosp, Dow Med Coll, Karachi, Pakistan

[4] Univ Munich, Klinikum Innenstadt, Friedrich Baur Inst, Munich, Germany

[5] Inst Natl Neurol, Tunis 1007, Tunisia

来源：

NEUROGENETICS | 1998年 / 2卷 / 01期

关键词：

recessive amyotrophic lateral sclerosis; chromosome; 15q15-q22; markers;

D O I：

10.1007/s100480050052

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Autosomal recessive familial amyotrophic lateral sclerosis (RFALS) is a rare form of ALS that usually presents at an early age with slow progression of symptoms. RFALS is clinically and genetically heterogeneous and the locus of REALS type 3 was mapped to 2q33 (ALS2) in a single family. We now report linkage of a more-common form of REALS to chromosome 15q15-q22 markers (ALS5) and show further genetic locus heterogeneity in REALS. ALS5 is the locus for most families with REALS and appears to be present in both North African and European populations.

引用

页码：55 / 60

页数：6

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