Mushroom spine dynamics in medium spiny neurons of dorsal striatum associated with memory of moderate and intense training

被引:59
作者
Bello-Medina, Paola C. [1 ]
Flores, Gonzalo [2 ]
Quirarte, Gina L. [1 ]
McGaugh, James L. [3 ,4 ]
Prado Alcala, Roberto A. [1 ]
机构
[1] Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Conductual & Cognit, Queretaro 76230, Mexico
[2] Benemerita Univ Autonoma Puebla, Inst Fisiol, Puebla 72570, Mexico
[3] Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA 92697 USA
[4] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA
关键词
dendritic spines; dorsal striatum; accumbens; memory consolidation; intense training; ANTERIOR CINGULATE CORTEX; DENDRITIC SPINES; NUCLEUS-ACCUMBENS; CAUDATE-NUCLEUS; RAT HIPPOCAMPUS; MORPHOLOGICAL-CHANGES; NEGATIVE REINFORCER; SUBSTANTIA-NIGRA; PROTECTS MEMORY; PYRAMIDAL CELLS;
D O I
10.1073/pnas.1613680113
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
A growing body of evidence indicates that treatments that typically impair memory consolidation become ineffective when animals are given intense training. This effect has been obtained by treatments interfering with the neural activity of several brain structures, including the dorsal striatum. The mechanisms that mediate this phenomenon are unknown. One possibility is that intense training promotes the transfer of information derived from the enhanced training to a wider neuronal network. We now report that inhibitory avoidance (IA) induces mushroom spinogenesis in the medium spiny neurons (MSNs) of the dorsal striatum in rats, which is dependent upon the intensity of the foot-shock used for training; that is, the effect is seen onlywhen high-intensity foot-shock is used in training. We also found that the relative density of thin spines was reduced. These changes were evident at 6 h after training and persisted for at least 24 h afterward. Importantly, foot-shock alone did not increase spinogenesis. Spine density in MSNs in the accumbens was also increased, but the increase did not correlate with the associative process involved in IA; rather, it resulted from the administration of the aversive stimulation alone. These findings suggest that mushroom spines of MSNs of the dorsal striatum receive afferent information that is involved in the integrative activity necessary for memory consolidation, and that intense training facilitates transfer of information from the dorsal striatum to other brain regions through augmented spinogenesis.
引用
收藏
页码:E6516 / E6525
页数:10
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