Synthesis of polysaccharides having specific biological activities

被引：129

作者：

Yoshida, T ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Sci, Dept Polymer Sci, Kita Ku, Sapporo, Hokkaido 0600810, Japan

来源：

PROGRESS IN POLYMER SCIENCE | 2001年 / 26卷 / 03期

关键词：

anhydro-sugars; anhydro-disaccharides; amino sugars; ring-opening polymerization; enzymatic polymerization; branched polysaccharides; amino polysaccharides; deoxy polysaccharides; sulfonated polysaccharides; anti-HIV activity; blood anti-coagulant activity; anti-tumor activity; wound healing activity;

D O I：

10.1016/S0079-6700(00)00045-9

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理]; 080501 [材料物理与化学]; 081704 [应用化学];

摘要：

Several types of stereoregular polysaccharides such as linear, branched, amino, and deoxy polysaccharides were synthesized by ring-opening polymerization of anhydro-sugar derivatives to reveal the relationship between structure and biological activities. Their stereoregular and naturally occurring polysaccharides were sulfonated. It was found that the sulfonated polysaccharides had potent anti-human immunodeficiency virus (anti-HIV) activities, which increased with an increase of the proportion of amino sugar and branched units on the main chain, but with a decrease of deoxy sugar units and branches. Another biological activity of sulfonated polysaccharides, blood anti-coagulant activity, was also examined. An overview will be presented of various synthetic and natural polysaccharides having biological activities. (C) 2001 Elsevier Science Ltd, All rights reserved.

引用

页码：379 / 441

页数：63

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