Genes and environmental exposures in veterans with amyotrophic lateral sclerosis: The GENEVA study

被引：29

作者：

Schmidt, Silke ^{[1
,2
]}

Allen, Kelli D. ^{[2
]}

Loiacono, Valerie T. ^{[1
,2
]}

Norman, Barbara ^{[2
]}

Stanwyck, Catherine L. ^{[1
,2
]}

Nord, Kristina M. ^{[1
,2
]}

Williams, Christina D. ^{[1
,2
]}

Kasarskis, Edward J. ^{[4
]}

Kamel, Freya ^{[3
]}

McGuire, Valerie ^{[5
]}

Nelson, Lorene M. ^{[5
]}

Oddone, Eugene Z. ^{[2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Ctr Human Genet, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[3] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA

[4] Univ Kentucky, Med Ctr, Lexington, KY USA

[5] Stanford Univ, Sch Med, Stanford, CA 94305 USA

来源：

NEUROEPIDEMIOLOGY | 2008年 / 30卷 / 03期

关键词：

amyotrophic lateral sclerosis; case-control study; GENEVA study recruitment methods; gene-environment interaction;

D O I：

10.1159/000126911

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Recent reports of a potentially increased risk of amyotrophic lateral sclerosis (ALS) for veterans deployed to the 1990-1991 Persian Gulf War prompted the Department of Veterans Affairs to establish a National Registry of Veterans with ALS, charged with the goal of enrolling all US veterans with a neurologist-confirmed diagnosis of ALS. The Genes and Environmental Exposures in Veterans with ALS study (GENEVA) is a case-control study presently enrolling cases from the Department of Veterans Affairs registry and a representative sample of veteran controls to evaluate the joint contributions of genetic susceptibility and environmental exposures to the risk of sporadic ALS. The GENEVA study design, recruitment strategies, methods of collecting DNA samples and environmental risk factor information are described here, along with a summary of demographic characteristics of the participants (537 cases, 292 controls) enrolled to date. Copyright (c) 2008 S. Karger AG, Basel.

引用

页码：191 / 204

页数：14

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