Two-dimensional hydrodynamic focusing in a simple microfluidic device

被引:87
作者
Simonnet, C [1 ]
Groisman, A [1 ]
机构
[1] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
基金
美国国家科学基金会;
关键词
D O I
10.1063/1.2046729
中图分类号
O59 [应用物理学];
学科分类号
摘要
Two-dimensional flow focusing in pressure-driven flow is demonstrated in a microfluidic device made of a single cast of a silicon elastomer. A stream injected into the device is shaped to a variety of rectangular profiles. A flow of particles is focused into a thin layer with homogeneous velocity. A blob of dye injected into a microchannel is transported over a long distance with minimal dispersion. The device can be integrated into lab-on-a-chip systems and used as a low-cost flow cytometry chamber.
引用
收藏
页数:3
相关论文
共 12 条
[1]  
[Anonymous], FLOW CYTOMETRY INSTR
[2]   A DEVICE FOR COUNTING SMALL PARTICLES SUSPENDED IN A FLUID THROUGH A TUBE [J].
CROSLANDTAYLOR, PJ .
NATURE, 1953, 171 (4340) :37-38
[3]  
Eyal S, 2002, ELECTROPHORESIS, V23, P2653, DOI 10.1002/1522-2683(200208)23:16<2653::AID-ELPS2653>3.0.CO
[4]  
2-H
[5]   Microfluidic memory and control devices [J].
Groisman, A ;
Enzelberger, M ;
Quake, SR .
SCIENCE, 2003, 300 (5621) :955-958
[6]   Experimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels [J].
Ismagilov, RF ;
Stroock, AD ;
Kenis, PJA ;
Whitesides, G ;
Stone, HA .
APPLIED PHYSICS LETTERS, 2000, 76 (17) :2376-2378
[7]   Hydrodynamic focusing on a silicon chip: Mixing nanoliters in microseconds [J].
Knight, JB ;
Vishwanath, A ;
Brody, JP ;
Austin, RH .
PHYSICAL REVIEW LETTERS, 1998, 80 (17) :3863-3866
[8]   Three-dimensional hydrodynamic focusing in polydimethylsiloxane (PDMS) microchannels [J].
Sundararajan, N ;
Pio, MS ;
Lee, LP ;
Berlin, AA .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2004, 13 (04) :559-567
[9]   Laminar flows - Subcellular positioning of small molecules [J].
Takayama, S ;
Ostuni, E ;
LeDuc, P ;
Naruse, K ;
Ingber, DE ;
Whitesides, GM .
NATURE, 2001, 411 (6841) :1016-1016
[10]   DISPERSION OF SOLUBLE MATTER IN SOLVENT FLOWING SLOWLY THROUGH A TUBE [J].
TAYLOR, G .
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL AND PHYSICAL SCIENCES, 1953, 219 (1137) :186-203