Synthesis of epibatidine isomers:: endo-5-and 6-(6′-chloro-3′-pyridyl-2-azabicyclo[2.2.1]heptanes

被引：31

作者：

Cox, CD

Malpass, JR ^{[1
]}

Gordon, J

Rosen, A

机构：

[1] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England

[2] AstraZeneca R&D Boston, Worcester, MA 01605 USA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / Royal Society of Chemistry卷 / 19期

关键词：

D O I：

10.1039/b106212n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of the title;compounds is described; detailed NMR data are provided in support of the proposed stereostructures. The 5- and 6-endo-compounds show high selectivity for alpha4 beta2 versus alpha7 nAChR subtypes; in contrast, the exo-stereoisomers show comparatively weak affinity at both subtypes.

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页码：2372 / 2379

页数：8

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