Epstein-Barr virus and human T-cell lymphomas

被引：33

作者：

Meijer, CJLM

Jiwa, NM

Dukers, DF

Oudejans, JJ

deBruin, PC

Walboomers, JMM

vandenBrule, AJC

机构：

[1] Department of Pathology, Free University Hospital, Amsterdam

来源：

SEMINARS IN CANCER BIOLOGY | 1996年 / 7卷 / 04期

关键词：

EBV infection; LMP1; T-NHL;

D O I：

10.1006/scbi.1996.0026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epstein-Barr virus has been classically associated with certain B-lymphocytic benign and malignant proliferations. However, using molecular biological techniques it becomes clear that EBV is also associated with several T-NHL in non-immunocompromised patients. The distribution of EBV-associated T-NHL seems to be site-restricted i.e. in about 100% of the nasal T-NHL and in 20% of the lung and gastrointestinal lymphomas and rarely in primary cutaneous T-cell lymphomas. Moreover, the expression of the LMP1 protein seems to be associated with a poor prognosis. In this section the role of EBV in the pathogenesis of T-NHL will be discussed.

引用

页码：191 / 196

页数：6

共 48 条

[1]

ANAGNOSTOPOULOS I, 1989, BLOOD, V74, P810

[2] Epstein-Barr virus genome in non-Hodgkin's lymphomas occurring in immunocompetent patients: Highest prevalence in nonlymphoblastic T-cell lymphoma and correlation with a poor prognosis [J].