Allovectin-7 therapy in metastatic melanoma

被引：21

作者：

Bedikian, Agop Y. ^{[1
]}

Del Vecchio, Michele ^{[2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USA

[2] Ist Nazl Tumori, Unit Med Oncol 2, Dept Med Oncol, I-20133 Milan, Italy

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2008年 / 8卷 / 06期

关键词：

Allovectin-7; DNA vaccination; immunotherapy; melanoma;

D O I：

10.1517/14712598.8.6.839

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: Patients with metastatic melanoma are immunosuppressed by the growing tumor. Allovectin-7 therapy is a form of active immunotherapy that aims at immunization of the host with substances designed to elicit an immune reaction that will eliminate or slow down the growth and spread of the cancer. Objective: to describe the rationale for immunotherapy with Allovectin-7 and assess its safety profile and efficacy based on the results of completed melanoma clinical trials. Methods: we reviewed both the published medical literature and the results of trials pending publication. Results/conclusion: Allovectin-7 is a safe and active immunotherapeutic agent. it induces local and systemic durable responses in patients with metastatic melanoma.

引用

页码：839 / 844

页数：6

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