学术探索
学术期刊
新闻热点
数据分析
智能评审

Tachykinins in the emerging immune system: Relevance to bone marrow homeostasis and maintenance of hematopoietic stem cells

被引：55
作者：
Greco, SJ
Corcoran, KE
Cho, KJ
Rameshwar, P
机构：
[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med Hematol Oncol, Newark, NJ 07103 USA
[2] UMDNJ, Grad Sch Biomed Sci, Interdisciplinary Program, Newark, NJ USA
[3] Korea Univ, Coll Hlth Sci, Dept Clin Lab Sci, Seoul 136701, South Korea
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2004年 / 9卷
关键词：
bone marrow; hematopoiesis; hematopoietic; stem cells; tachykinins; cytokines; review;
D O I：
10.2741/1373
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mammalian tachykinins mediate crosstalk within the neural-immune-hematopoietic axis. Hematopoiesis occurs in the adult bone marrow ( BM) and it is described as the method by which the immune system is replenished by a finite number of hematopoietic stem cells (HSC). These cells are found in the BM close to the endosteum where the oxygen level is the lowest. The BM is also resident to mesenchymal stem cell (MSC). The functions of HSC depend on the MSC to generate the supporting stromal cells. This review discusses possible mechanisms by which the MSC act as the 'gatekeeper' in the BM and regulate immune cells in and out of the BM. The roles of the tachykinins are discussed in the context of homeostasis in the BM and as mediators of BM disruption. The involvement of the tachykinins within the BM microenvironment and the development of immune cells in the BM are explained.
引用
收藏
页码：1782 / 1793
页数：12
相关论文
共 97 条
[1]  
Adamus MA, 2001, J CELL BIOCHEM, V81, P499, DOI 10.1002/1097-4644(20010601)81:3<499::AID-JCB1063>3.0.CO
[2]  
2-Y
[3]   Bone marrow innervation regulates cellular retention in the murine haemopoietic system [J].
Afan, AM ;
Boome, CS ;
Nicholls, SE ;
Whetton, AD ;
Miyan, JA .
BRITISH JOURNAL OF HAEMATOLOGY, 1997, 98 (03) :569-577
[4]   The chemokine SDF-1 is a chemoattractant for human CD34(+) hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34(+) progenitors to peripheral blood [J].
Aiuti, A ;
Webb, IJ ;
Bleul, C ;
Springer, T ;
GutierrezRamos, JC .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (01) :111-120
[5]   Hematopoietic failure after hemorrhagic shock is mediated partially through mesenteric lymph [J].
Anjaria, DJ ;
Rameshwar, P ;
Deitch, EA ;
Xu, DZ ;
Adams, CA ;
Forsythe, RM ;
Sambol, JT ;
Hauser, CJ ;
Livingston, DH .
CRITICAL CARE MEDICINE, 2001, 29 (09) :1780-1785
[6]   Crosstalk between neurokinin receptors is relevant to hematopoietic regulation: cloning and characterization of neurokinin-2 promoter [J].
Bandari, PS ;
Qian, J ;
Oh, HS ;
Potian, JA ;
Yehia, G ;
Harrison, JS ;
Rameshwar, P .
JOURNAL OF NEUROIMMUNOLOGY, 2003, 138 (1-2) :65-75
[7]   Hematopoietic growth factor inducible neurokinin-1 type: a transmembrane protein that is similar to neurokinin 1 interacts with substance P [J].
Bandari, PS ;
Qian, J ;
Yehia, G ;
Joshi, DD ;
Maloof, PB ;
Potian, J ;
Oh, HS ;
Gascon, P ;
Harrison, JS ;
Rameshwar, P .
REGULATORY PEPTIDES, 2003, 111 (1-3) :169-178
[8]   Differences in the expression of neurokinin receptor in neural and bone marrow mesenchymal cells: implications for neuronal expansion from bone marrow cells [J].
Bandari, PS ;
Qian, J ;
Yehia, G ;
Seegopaul, HP ;
Harrison, JS ;
Gascon, P ;
Fernandes, H ;
Rameshwar, P .
NEUROPEPTIDES, 2002, 36 (01) :13-21
[9]   Pharmacological profile of the novel mammalian tachykinin, hemokinin 1 [J].
Bellucci, F ;
Carini, F ;
Catalani, C ;
Cucchi, P ;
Lecci, A ;
Meini, S ;
Patacchini, R ;
Quartara, L ;
Ricci, R ;
Tramontana, M ;
Giuliani, S ;
Maggi, CA .
BRITISH JOURNAL OF PHARMACOLOGY, 2002, 135 (01) :266-274
[10]   Effects of kindled seizures upon hematopoiesis in rats [J].
Bhatt, R ;
Rameshwar, P ;
Goldstein, K ;
Siegel, A .
EPILEPSY RESEARCH, 2003, 54 (2-3) :209-219
12345678910