Gene expression profiling of high altitude polycythemia in Han Chinese migrating to the Qinghai-Tibetan plateau

被引：37

作者：

Jiang, Ci Unhua ^{[1
,2
,3
]}

Liu, Fuyu ^{[2
,3
]}

Luo, Yongjun ^{[2
,3
,4
]}

Li, Peng ^{[2
,3
,5
]}

Chen, Jian ^{[1
,2
,3
]}

Xu, Gang ^{[2
,3
]}

Wang, Yujie ^{[1
,2
,3
]}

Li, Xiaoxu ^{[2
,3
]}

Huang, Jian ^{[1
,2
,3
]}

Gao, Yuqi ^{[1
,2
,3
]}

机构：

[1] Third Mil Med Univ, Coll High Altitude Mil Med, Dept Pathophysiol & High Altitude Physiol, Chongqing 400038, Peoples R China

[2] Minist Educ, Key Lab High Altitude Med, Chongqing 400038, Peoples R China

[3] PLA, Key Lab High Altitude Med, Chongqing 400038, Peoples R China

[4] Third Mil Med Univ, Coll High Altitude Mil Med, Dept High Altitude Dis, Chongqing 400038, Peoples R China

[5] Third Mil Med Univ, Coll High Altitude Mil Med, Dept High Altitude Mil Hyg, Chongqing 400038, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2012年 / 5卷 / 01期

基金：

美国国家科学基金会;

关键词：

altitude; hypoxia; polycythemia; chronic mountain sickness gene expression profiling; microarray; CHRONIC MOUNTAIN-SICKNESS; HEMATOPOIETIC STEM-CELL; HEMOGLOBIN CONCENTRATION; CYTOCHROME-P450; 1B1; VERSICAN; HYPOXIA; CDC42; ERYTHROPOIETIN; PROLIFERATION; MECHANISMS;

D O I：

10.3892/mmr.2011.632

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Chronic mountain sickness (CMS) is a condition in which the hematocrit is increased above the normal level in residents at high altitude. High altitude polycythemia (HA PC) is the most characteristic sign of CMS. However, the pathogenesis of HAPC is poorly understood. The present study aimed to investigate the gene expression profile of HA PC in Han Chinese migrating to the Qinghai-Tibetan Plateau and to identify he pathogenetic mechanisms. A total of 9 differentially expressed genes were identified in HAPC patients using microarrays: 5 were up-regulated and 4 were down-regulated. Functional analysis of the array data revealed that cell division cycle 42 (CDC42) and the human immune response may be key feat res underlying the mechanism and development of HA PC.

引用

页码：287 / 293

页数：7

共 47 条

[1]

Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion [J].