Targeting T Cell Co-receptors for Cancer Therapy

被引：408

作者：

Callahan, Margaret K. ^{[1
,2
]}

Postow, Michael A. ^{[1
,2
]}

Wolchok, Jedd D. ^{[1
,2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, Melanoma & Immunotherapeut Serv, New York, NY 10065 USA

[2] Cornell Univ, Weill Cornell Med Coll, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY 10065 USA

来源：

IMMUNITY | 2016年 / 44卷 / 05期

关键词：

LYMPHOCYTE-ASSOCIATED ANTIGEN-4; IPILIMUMAB PLUS DACARBAZINE; RESISTANT PROSTATE-CANCER; METASTATIC MELANOMA; UNTREATED MELANOMA; LUNG-CANCER; PD-1; BLOCKADE; PHASE-3; TRIAL; AUTOIMMUNE HYPOPHYSITIS; ANTI-PD-L1; ANTIBODY;

D O I：

10.1016/j.immuni.2016.04.023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Checkpoint-blocking antibodies can generate potent anti-tumor responses by encouraging the immune system to seek and destroy cancer cells. At this time, the United States Food and Drug Administration has approved three checkpoint-blocking antibodies in three disease indications, and additional approvals are expected to broaden the clinical scope of immunotherapy. Herein, we review the clinical development of CTLA-4-, PD-1-, and PD-L1-blocking antibodies across tumor types and briefly discuss areas of active investigation of potential biomarkers.

引用

页码：1069 / 1078

页数：10

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