The early fall in levels of S-100 β in traumatic brain injury

被引:67
作者
Jackson, RGM
Samra, GS [1 ]
Radcliffe, J
Clark, GH
Price, CP
机构
[1] Royal London Hosp, Acad Dept Anaesthesia & Intens Care, Anaesthet Unit, London E1 1BB, England
[2] Royal London Hosp, Dept Clin Biochem, London E1 1BB, England
关键词
S-100; protein; outcome; head injury; blood;
D O I
10.1515/CCLM.2000.179
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Protein S-100 beta has been suggested as a prognostic marker in traumatic brain injury, However, little is known of its behaviour in the immediate post-injury period. With Ethics Committee approval, we recruited 30 patients with a history of head injury presenting to our Accident and Emergency Department. Blood was taken on arrival and at four hours post-injury. Serum S-100 beta was estimated using an immunoluminometric assay. Levels of S-100 beta were seen to fall rapidly with time. Half-time was distributed non-parametrically with a median of 198 minutes. Using the Mann-Whitney U test we found a statistically significant difference between non-desirable (Glasgow Outcome Score 1-3) and desirable (Glasgow Outcome Score 4-5) outcome on admission (p = 0.0155) but not at four hours (p = 0.1336). Levels of S-100 beta fell rapidly after its release following traumatic brain injury. Time after injury is therefore critical in assessing the significance of levels of S-100 beta, and sampling should be as early as possible to gain maximum information. If S-100 beta is to be assessed as a monitor of ongoing brain injury in the intensive therapy unit sampling must be frequent (e.g. every 4 hours) to be able to detect rises in serum levels before they have decayed to baseline.
引用
收藏
页码:1165 / 1167
页数:3
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