Serotonin inhibits the induction of long-term potentiation in rat primary visual cortex

被引：18

作者：

Edagawa, Y ^{[1
]}

Saito, H ^{[1
]}

Abe, K ^{[1
]}

机构：

[1] Univ Tokyo, Fac Pharmaceut Sci, Dept Chem Pharmacol, Bunkyo Ku, Tokyo 1130033, Japan

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1998年 / 22卷 / 06期

关键词：

long-term potentiation; primary visual cortex; serotonin;

D O I：

10.1016/S0278-5846(98)00055-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. The effect of serotonin (5-hydroxytryptamine; 5-HT) on the induction of long-term potentiation (LTP) in rat visual cortex was investigated by using slice preparations in vitro. 2. Bath application of 5-HT (0.1-10 mu M) did not affect the baseline synaptic potentials evoked by single-pulse test stimulation, but inhibited the induction of LTP in a concentration-dependent manner. 3. The effect of 5-HT was blocked by the 5-HT1 receptor antagonist pindolol or the 5-HT2,7 receptor antagonist ritanserin, but not by the 5-HT3,4 receptor antagonist MDL72222. 4. These results suggest that 5-HT plays a role in suppressing the induction of LTP in the rat visual cortex.

引用

页码：983 / 997

页数：15

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