Quorum sensing and its relevance to infectious diseases

被引:68
作者
Donabedian, H [1 ]
机构
[1] Med Coll Ohio, Div Infect Dis, Dept Internal Med, Toledo, OH 43614 USA
[2] Med Coll Ohio, Div Infect Dis, Dept Internal Med, Toledo, OH 43614 USA
[3] Med Coll Ohio, Div Infect Dis, Dept Microbiol, Toledo, OH 43614 USA
[4] Med Coll Ohio, Div Infect Dis, Dept Immunol, Toledo, OH 43614 USA
关键词
D O I
10.1053/jinf.2002.1120
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Quorum sensing allows bacteria to detect the density of their own species and alter their metabolism to take advantage of this density. Quorum sensing is used by a wide variety of bacteria including human pathogens. Quorum sensing genes are important for the pathogenic potential of Pseudomonas aeruginosa and Staphylococcus aureus, as well as other invasive bacteria. An understanding of quorum sensing may lead to new therapeutic strategies. (C) 2003 The British Infection Society. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:207 / 214
页数:8
相关论文
共 52 条
  • [1] THE ACCESSORY GENE REGULATOR (AGR) CONTROLS STAPHYLOCOCCUS-AUREUS VIRULENCE IN A MURINE ARTHRITIS MODEL
    ABDELNOUR, A
    ARVIDSON, S
    BREMELL, T
    RYDEN, C
    TARKOWSKI, A
    [J]. INFECTION AND IMMUNITY, 1993, 61 (09) : 3879 - 3885
  • [2] AUTOCRINE REGULATION OF TOXIN SYNTHESIS BY STAPHYLOCOCCUS-AUREUS
    BALABAN, N
    NOVICK, RP
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) : 1619 - 1623
  • [3] Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa
    Calfee, MW
    Coleman, JP
    Pesci, EC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) : 11633 - 11637
  • [4] The involvement of cell-to-cell signals in the development of a bacterial biofilm
    Davies, DG
    Parsek, MR
    Pearson, JP
    Iglewski, BH
    Costerton, JW
    Greenberg, EP
    [J]. SCIENCE, 1998, 280 (5361) : 295 - 298
  • [5] Bacterial quorum sensing in pathogenic relationships
    de Kievit, TR
    Iglewski, BH
    [J]. INFECTION AND IMMUNITY, 2000, 68 (09) : 4839 - 4849
  • [6] Quorum-sensing genes in Pseudomonas aeruginosa biofilms:: Their role and expression patterns
    De Kievit, TR
    Gillis, R
    Marx, S
    Brown, C
    Iglewski, BH
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2001, 67 (04) : 1865 - 1873
  • [7] Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase
    Dong, YH
    Wang, LH
    Xu, JL
    Zhang, HB
    Zhang, XF
    Zhang, LH
    [J]. NATURE, 2001, 411 (6839) : 813 - 817
  • [8] Quorum sensing: A novel target for anti-infective therapy
    Finch, RG
    Pritchard, DI
    Bycroft, BW
    Williams, P
    Stewart, GSAB
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (05) : 569 - 571
  • [9] Census and consensus in bacterial ecosystems: The LuxR-LuxI family of quorum-sensing transcriptional regulators
    Fuqua, C
    Winans, SC
    Greenberg, EP
    [J]. ANNUAL REVIEW OF MICROBIOLOGY, 1996, 50 : 727 - 751
  • [10] CLONING AND CHARACTERIZATION OF THE PSEUDOMONAS-AERUGINOSA LASR GENE, A TRANSCRIPTIONAL ACTIVATOR OF ELASTASE EXPRESSION
    GAMBELLO, MJ
    IGLEWSKI, BH
    [J]. JOURNAL OF BACTERIOLOGY, 1991, 173 (09) : 3000 - 3009