Prognostic value of DNA ploidy and proliferating cell nuclear antigen in gastric cancer

被引：8

作者：

Hirose, K ^{[1
]}

Iida, A ^{[1
]}

Yamaguchi, A ^{[1
]}

Onchi, H ^{[1
]}

Awata, H ^{[1
]}

Katayama, K ^{[1
]}

Nakagawara, G ^{[1
]}

机构：

[1] Fukui Med Sch, Dept Surg 1, Fukui 91011, Japan

来源：

ONCOLOGY | 1998年 / 55卷 / 04期

关键词：

gastric cancer; DNA ploidy; proliferating cell nuclear antigen; lymph node metastasis;

D O I：

10.1159/000011867

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA ploidy and the labeling index (LI) of proliferating cell nuclear antigen (PCNA) in gastric cancers were determined using cytofluorometry and immunohistochemistry, respectively, and the prognostic value of these two parameters was evaluated. Of 66 patients with advanced gastric cancers treated with radical resection, 27 with aneuploidy and a high PCNA-LI (greater than or equal to 40) showed the lowest 5-year survival rate (38%). Twenty patients with diploid cancers and a high LI showed a lower 5-year survival rate (59%) than the 15 patients with diploid cancers and a low LI (<40), who had the highest 5-year survival rate (86%). A multivariate analysis showed that the grouping based on the ploidy and the LI was an independent prognostic factor. Thus, the combination of DNA ploidy and PCNA-LI may be a useful prognostic indicator for advanced gastric cancers.

引用

页码：300 / 306

页数：7

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