The αβ T cell repertoire comes into focus

被引：4

作者：

Davis, Mark M. ^{[1
]}

机构：

[1] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

来源：

IMMUNITY | 2007年 / 27卷 / 02期

关键词：

D O I：

10.1016/j.immuni.2007.08.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The size of the lymphocyte repertoire is of great interest, but direct information has been elusive. Moon et al. (2007) report the enumeration and isolation of naive CD4(+) T cells and show their numbers could predict the size and diversity of the primary immune response.

引用

页码：179 / 180

页数：2

共 10 条

[1] Individual variations in the murine T cell response to a specific peptide reflect variability in naive repertoires [J].

Bousso, P ;

Casrouge, A ;

Altman, JD ;

Haury, M ;

Kanellopoulos, J ;

Abastado, JP ;

Kourilsky, P .

IMMUNITY, 1998, 9 (02) :169-178

[2] DIVERSITY OF INFLUENZA-SPECIFIC PRIMARY B-CELL REPERTOIRE IN BALB-C MICE [J].

CANCRO, MP ;

GERHARD, W ;

KLINMAN, NR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1978, 147 (03) :776-787

[3] Size estimate of the αβ TCR repertoire of naive mouse splenocytes [J].

Casrouge, A ;

Beaudoing, E ;

Dalle, S ;

Pannetier, C ;

Kanellopoulos, J ;

Kourilsky, P .

JOURNAL OF IMMUNOLOGY, 2000, 164 (11) :5782-5787

[4] T-CELL ANTIGEN RECEPTOR GENES AND T-CELL RECOGNITION [J].

DAVIS, MM ;

BJORKMAN, PJ .

NATURE, 1988, 334 (6181) :395-402

[5] In vivo activation of antigen-specific CD4 T cells [J].

Jenkins, MK ;

Khoruts, A ;

Ingulli, E ;

Mueller, DL ;

McSorley, SJ ;

Reinhardt, RL ;

Itano, A ;

Pape, KA .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :23-45

[6]

KINDT TJ, 1984, ANTIBODY ENLGMA

[7] Detection of low-avidity CD4+ T cells using recombinant artificial APC:: Following the antiovalbumin immune response [J].

Mallet-Designe, VI ;

Stratmann, T ;

Homann, D ;

Carbone, F ;

Oldstone, MBA ;

Teyton, L .

JOURNAL OF IMMUNOLOGY, 2003, 170 (01) :123-131

[8] ANTIGEN-SPECIFIC DEVELOPMENT OF PRIMARY AND MEMORY T-CELLS IN-VIVO [J].

MCHEYZERWILLIAMS, MG ;

DAVIS, MM .

SCIENCE, 1995, 268 (5207) :106-111

[9] Naive CD4+ T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude [J].

Moon, James J. ;

Chu, H. Hamlet ;

Pepper, Marion ;

McSorley, Stephen J. ;

Jameson, Stephen C. ;

Kedl, Ross M. ;

Jenkins, Marc K. .

IMMUNITY, 2007, 27 (02) :203-213

[10] MHC class II tetramers identify peptide-specific human CD4+ T cells proliferating in response to influenza A antigen [J].

Novak, EJ ;

Liu, AW ;

Nepom, GT ;

Kwok, WW .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (12) :R63-R67

← 1 →